It takes the average reader 8 hours and 30 minutes to read Cancer Genomics by Francesca Cottini
Assuming a reading speed of 250 words per minute. Learn more
Multiple myeloma (MM) is a clonal proliferation of abnormal plasma cells in the bone marrow (BM), associated with a monoclonal protein and end-organ damage. MM originates from a pre-malignant condition, called monoclonal gammopathy of undetermined significance (MGUS) and can progress to an extramedullary disease, termed plasma cell leukemia (PCL), which invades the bloodstream. MM cells manifest a wide spectrum of genomic abnormalities, creating a strong intertumoral heterogeneity. Historically, MM patients have been divided into two subgroups: hyperdiploid cases (with >46 chromosomes) and non-hyperdiploid cases. However, the introduction of novel technologies such as fluorescence in situ hybridization (FISH), array comparative genomic hybridization (aCGH) and sequencing techniques is helping to unveil the complexity of MM genomes. In particular, MM cells present: recurrent translocations which deregulate known oncogenes, such as CCND1, FGFR3-MMSET, c-MAF and MYC, numerous copy number variations (CNVs) including deletion of chromosome 13, deletion of chromosome 17p13, and amplification of chromosome 1q21; and various somatic mutations in genes involved in cancer proliferation (RAS, BRAF, FGFR3), protein homeostasis and RNA processing (FAM46C, DIS3, XBP1 and LRRK2); NF-κB signaling; histone methylation; and tumor suppression (TP53). This chapter will summarize our current knowledge of the MM genomic field, focusing on the different types of abnormalities and their relationship with the phases of disease.
Cancer Genomics by Francesca Cottini is 510 pages long, and a total of 127,500 words.
This makes it 172% the length of the average book. It also has 156% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 11 hours and 36 minutes to read Cancer Genomics aloud.
Cancer Genomics is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
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