It takes the average reader 9 hours and 25 minutes to read Computational Systems Biology by Joseph Xu Zhou
Assuming a reading speed of 250 words per minute. Learn more
In this chapter, we introduced the basic concepts of cell attractors and showed that Waddington’s metaphoric epigenetic landscape has a formal basis in the attractor landscape. This conceptual framework helps to understand core properties of cell differentiation and ultimately, multicellularity. Specifically, we developed the concept of relative stability of network states on the epigenetic landscape, thus providing the elevation in the landscape picture a formal, quantifiable basis. We proposed methods to quantify the relative stability of attractor states in discrete gene networks models. We show in two examples that even with incomplete information about network structures, the use of Boolean networks can capture the essential outlines of cell fate dynamics and more importantly, permit the estimation of relative stability and the attractor transition barriers. These measures hold great promise for the rational design of the perturbation protocols for cell reprogramming in regenerative medicine. As the knowledge of the structure of GRNs for the development of various tissues will undoubtedly increase in the next decade, the utilization of such network information for therapeutic reprogramming may benefit from the concepts developed here.
Computational Systems Biology by Joseph Xu Zhou is 548 pages long, and a total of 141,384 words.
This makes it 185% the length of the average book. It also has 173% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 12 hours and 52 minutes to read Computational Systems Biology aloud.
Computational Systems Biology is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
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