It takes the average reader 1 hour and 2 minutes to read Effect of RU486 on Development of Sexual Behavior, Testosterone Secretion, and Expression of Estrogen Receptor-[beta] in Twin-born Male Lambs by Priyanka S. Singh
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It was hypothesized that progesterone influences the development and expression of male sexual behavior in rams. Twin born male lambs (n = 10) were used in this study. One lamb from each pair was treated with 10 mg of the progesterone receptor (PR) antagonist, RU486 (n = 5) and his co-sibling was treated with an equal volume of vehicle twice daily from 4 to 8 wk of age. Serum concentrations of testosterone tended to be decreased (P = 0.06) in RU486 treated rams at 9 mo, but did not differ (P = 0.5) at 18 mo of age. Investigatory (anogenital sniff + nudge + flehmen + foreleg kick) behavior at 9 mo of age was decreased (P = 0.03) by RU486 treatment at the first exposure to estrous ewes, but consummatory (attempt to mount + mount + ejaculation) behavior did not differ (P [greater than or equal to] 0.24). By 18 mo of age, sexual behavior was not (investigatory P [greater than or equal to] 0.47, consummatory P [greater than or equal to] 0.56) influenced by treatment. Expression of steroid receptors were evaluated in hypothalamic and amygdala tissues collected at 18 mo of age. Amygdala expression of estrogen receptor-[beta] tended (P = 0.08) to be increased in RU486 treated rams. Hypothalamic expression of progesterone receptor (PR), estrogen receptor-[alpha], (ER-[alpha]), (ER-[beta]) and androgen receptor (AR) did not differ (P [greater than or equal to] 0.3) among treatments. In summary, blocking the PR during postnatal sexual development decreased sexual behavior when adolescent rams were first exposed to estrous ewes. Subsequent behaviors may be a result of an incomplete inhibition of the PR during development or increased positive stimuli provided by the rewarding aspects of sexual behavior.
Effect of RU486 on Development of Sexual Behavior, Testosterone Secretion, and Expression of Estrogen Receptor-[beta] in Twin-born Male Lambs by Priyanka S. Singh is 62 pages long, and a total of 15,624 words.
This makes it 21% the length of the average book. It also has 19% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 1 hour and 25 minutes to read Effect of RU486 on Development of Sexual Behavior, Testosterone Secretion, and Expression of Estrogen Receptor-[beta] in Twin-born Male Lambs aloud.
Effect of RU486 on Development of Sexual Behavior, Testosterone Secretion, and Expression of Estrogen Receptor-[beta] in Twin-born Male Lambs is suitable for students ages 8 and up.
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