How Long to Read Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation

How Long Does it Take to Read Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation?

It takes the average reader 6 hours and 10 minutes to read Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation by Sarah Elizabeth Gilpin

Assuming a reading speed of 250 words per minute. Learn more

Description

Bone marrow-derived progenitor cell populations have been implicated in tissue regeneration and also in human disease pathology. This thesis investigated the hypothesis that Clara Cell Secretory Protein positive (CCSP+) epithelial-like progenitor cells and circulating fibrocyte numbers are altered in human lung disease and injury, and aimed to determine the predictive value of these cell profiles. It was found that cystic fibrosis patients have an increased number of CCSP+ cells in their bone marrow and peripheral blood, while patients with bronchiolitis obliterans syndrome (BOS) have a decreased number. In addition, BOS and pulmonary fibrosis patients have increased circulating fibrocytes. In response to ischemia reperfusion injury, an increase in CCSP+ cells in the peripheral blood was found at 24 hrs following lung transplant. Lastly, in patients studied greater than 1-year from transplant, those diagnosed with BOS had a higher number of fibrocytes and a loss of CCSP+ peripheral blood cells when compared to patients with stable lung function, with increased fibrocytes being associated with time post-transplant. In these patients, the ratio of fibrocytes-to-CCSP+ cells was predictive of lung function.Multiplex protein arrays were used to investigate corresponding patient plasma, aiming to elucidate key mediators of progenitor cell recruitment. While differences in various cytokines were found between end-stage diseases, a specific relationship between Stem Cell Growth Factor-beta and CCSP + cells was identified and between Monocyte Chemotactic Protein-1 and fibrocytes. Conversely, response of CCSP+ cells following transplant appears to be mediated by known mobilizing factors SDF-1 and GM-CSF. Interestingly, in patients followed long-term after transplant, MCP-1 was associated with the number of CCSP+ cells, while SDF-1 correlated with fibrocyte numbers. These observations suggest common pathways acting on both populations that may be altered by the microenvironment, and may further suggest a common origin. This work contributes important information regarding changes in lung progenitor cells and their association with human disease and tissue repair, which could ultimately support future directions that directly advance therapy and improve patient care.

How long is Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation?

Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation by Sarah Elizabeth Gilpin is 370 pages long, and a total of 92,500 words.

This makes it 125% the length of the average book. It also has 113% more words than the average book.

How Long Does it Take to Read Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation Aloud?

The average oral reading speed is 183 words per minute. This means it takes 8 hours and 25 minutes to read Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation aloud.

What Reading Level is Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation?

Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation?

Human Lung Progenitor Populations in End-Stage Lung Disease and Transplantation by Sarah Elizabeth Gilpin is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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