It takes the average reader 1 hour and 49 minutes to read Molecular Mechanisms Integrating Genetic and Calcium Activity-dependent Neurotransmitter Specification by Lisa Miriam Kurtz
Assuming a reading speed of 250 words per minute. Learn more
Excitability regulates many aspects of neuronal differentiation in addition to forming the basis for rapid signaling in the mature nervous system. Several key features that determine the functional activity of neurons are modulated by calcium signaling during development, including neurotransmitter specification. The focus of the dissertation is on understanding the signaling cascades that mediate calcium spike-dependent specification of neurotransmitter phenotype in embryonic spinal neurons. I describe the identification and characterization of novel pathways that act in the specification of activity-dependent neurotransmitter phenotype by targeted screening of molecules known to regulate the expression of excitatory and inhibitory neurotransmitters. In addition, I describe a gain-of-function screen to identify novel molecules that were previously unknown to play a role in the activity-dependent specification of neurotransmitter phenotype. Finally, I describe the generation and development of novel transgenic Xenopus lines in which specific subsets of neurons are fluorescently labeled. These lines serve as the basis for further genetic screening and can be used to characterize the activity-dependent specification of neurotransmitters as well as numerous other processes in neuronal development.
Molecular Mechanisms Integrating Genetic and Calcium Activity-dependent Neurotransmitter Specification by Lisa Miriam Kurtz is 107 pages long, and a total of 27,499 words.
This makes it 36% the length of the average book. It also has 34% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 2 hours and 30 minutes to read Molecular Mechanisms Integrating Genetic and Calcium Activity-dependent Neurotransmitter Specification aloud.
Molecular Mechanisms Integrating Genetic and Calcium Activity-dependent Neurotransmitter Specification is suitable for students ages 10 and up.
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