How Long to Read Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor

How Long Does it Take to Read Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor?

It takes the average reader 2 hours and 30 minutes to read Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor by Patrick Neil McCormick

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Description

In vivo imaging of the D2 receptor with agonist radiotracers could provide important information on the high-affinity, functional state of the D2 receptor in schizophrenia and Parkinson's disease. Here the D2 agonist [11C]-(+)-PHNO was evaluated for use as an agonist PET radiotracer. In vitro, (+)-PHNO was shown, through competitive binding experiments and functional assays for D2 agonism, to be a potent full agonist at the D2 receptor. Ex vivo in rats, [11C]-(+)-PHNO readily crossed the blood-brain barrier and accumulated preferentially in the D2-rich striatum. [11C]-(+)-PHNO pharmacokinetics were rapid, with peak accumulation 5 min after tail-vein injection. The striatal binding of [11C]-(+)-PHNO was highly stereo selective, saturable, had pharmacology appropriate for D2 receptor binding and was sensitive to both increases and decreases in the concentration of endogenous dopamine. These characteristics make [11C]-(+)-PHNO a promising candidate for in vivo imaging of the high-affinity, functional state of the D2 receptor in humans using PET.

How long is Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor?

Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor by Patrick Neil McCormick is 150 pages long, and a total of 37,500 words.

This makes it 51% the length of the average book. It also has 46% more words than the average book.

How Long Does it Take to Read Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor Aloud?

The average oral reading speed is 183 words per minute. This means it takes 3 hours and 24 minutes to read Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor aloud.

What Reading Level is Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor?

Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

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Where Can I Buy Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor?

Pre-clinical Evaluation of [carbon-11]-(+)-PHNO as an Agonist Positron Emission Tomography (PET) Radiotracer for Imaging of the High-affinity State of the Dopamine D2 Receptor by Patrick Neil McCormick is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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