It takes the average reader 3 hours and 43 minutes to read Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease by Pura Muñoz-Cánoves
Assuming a reading speed of 250 words per minute. Learn more
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease by Pura Muñoz-Cánoves is 222 pages long, and a total of 55,944 words.
This makes it 75% the length of the average book. It also has 68% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 5 hours and 5 minutes to read Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease aloud.
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
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