How Long to Read The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies

How Long Does it Take to Read The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies?

It takes the average reader 2 hours and 4 minutes to read The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies by Valerie Trapp

Assuming a reading speed of 250 words per minute. Learn more

Description

Angiogenesis is critical for cancer development and progression. Anti-angiogenic agents have been shown to have clinical activity in several tumor types, including melanoma. Unfortunately these therapies are effective only in a minority of patients and are toxic and expensive. Development of a predictive technology that could identify those patients most likely to respond would decrease the risk to benefit ratio. We constructed a three-dimensional model of tumor angiogenesis and used the model to demonstrate (1) that a subset of cancer cells expressing thrombospondin-1 (TSP1) could sensitize vascular endothelial cells (VECs) to anti-angiogenic therapy, (2) that VECs sensitive to anti-angiogenic therapy also have inherent properties, including up-regulation of TSP1, and (3) the importance of using a model of angiogenesis which incorporates a tumor compartment. TSP1 is a natural inhibitor of angiogenesis. We hypothesized that VEC diapedesis would be blunted and that VECs would be more sensitive to anti-angiogenic agents when VECs were co-cultured with tumor spheroids producing high levels of TSP1 versus low levels of TSP1. We found high TSP1 to be related to decreased VEC survival and increased sensitivity to anti-angiogenic agents in our in vitro model. Resveratrol, a natural polyphenol, has been shown to have both a cardio-protective and anti-angiogenic effect. We showed that while resveratrol had a protective/proliferative effect on endothelial cells grown by themselves in monolayer, it promoted endothelial cell apoptosis when endothelial cells were grown with cancer cells in our co-culture model. These phenomena are reminiscent of what is seen in vivo and demonstrate the importance of using a model of tumor angiogenesis that incorporates a tumor compartment.

How long is The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies?

The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies by Valerie Trapp is 123 pages long, and a total of 31,119 words.

This makes it 42% the length of the average book. It also has 38% more words than the average book.

How Long Does it Take to Read The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies Aloud?

The average oral reading speed is 183 words per minute. This means it takes 2 hours and 50 minutes to read The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies aloud.

What Reading Level is The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies?

The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies?

The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies by Valerie Trapp is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

To buy The Design of a Three-dimensional Spheroidal Model of Tumor Angiogenesis and Its Implementation in Anti-angiogenesis Studies by Valerie Trapp on Amazon click the button below.