How Long to Read The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease

How Long Does it Take to Read The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease?

It takes the average reader 1 hour and 48 minutes to read The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease by Kevin Robert Kipp

Assuming a reading speed of 250 words per minute. Learn more

Description

HDAC inhibition slows disease progression with no clear relationship to polycystin-1 (PC1) activity. I report here that the carboxyl-terminal tail of PC1 interacts with at least two acetyl transferases, p300/CBP Associated Factor (P/CAF) and alpha-Tubulin Acetyl Transferase (alphaTAT1). Using an antibody against acetylated lysine, the cytoplasmic carboxy-terminal tail fragment of PC-1 is constitutively acetylated and this signal is dependent on a region of the protein that lacks any lysine residues. Mutations to conserved lysine residues increased transcription factor signaling, while a single mutation in the interaction region disrupts this signaling. This data would support PC-1 activity acting as a counter-balance to the activity of HDACs, and thereby provide a potential explanation for success found in the use of HDAC inhibitors on the disease.

How long is The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease?

The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease by Kevin Robert Kipp is 106 pages long, and a total of 27,136 words.

This makes it 36% the length of the average book. It also has 33% more words than the average book.

How Long Does it Take to Read The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease Aloud?

The average oral reading speed is 183 words per minute. This means it takes 2 hours and 28 minutes to read The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease aloud.

What Reading Level is The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease?

The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease?

The Development of Targeted and Alternative Approaches in the Treatment of Autosomal Dominant Polycystic Kidney Disease by Kevin Robert Kipp is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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