How Long to Read The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States

How Long Does it Take to Read The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States?

It takes the average reader 5 hours and 44 minutes to read The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States by Timothy Scott Davison

Assuming a reading speed of 250 words per minute. Learn more

Description

P53 is a homotetrameric, tumor suppressor protein involved in transcriptional control of genes that regulate cell proliferation and death. In order to investigate the role that oligomerization plays in this capacity, the malleability of the sequence-structure relationship as it pertains to the quaternary structure, stability and oligomeric status of p53 is examined. This is achieved through scrutinizing the impact of two cancer-causing germline mutations found within the oligomerization domain and the analysis of hydrophobic to hydrophilic, single and double point mutations at the dimer-dimer interface, culminating in the design and structural characterization of a dimeric form of p53 by NMR. These studies produced a set of biophysically characterized p53 mutants with altered oligomeric status including monomers, dimers and destabilized tetramers ideal for probing the dependence of p53 function on oligomeric status. Specifically, studies involving the two germline mutations indicate that even partial abrogation of p53 oligomerization is sufficient for accelerated tumour progression. The prospect of functional interactions amongst p53 family members, including the p53 homologs p63 and p73, via conserved oligomerization domains is also assessed. Evidence is presented to show that the oligomerization domains of p63 and p73 preferentially fold into stable homotetramers, can form weak heterotetramers, but do not hetero-oligomerize with p53.

How long is The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States?

The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States by Timothy Scott Davison is 336 pages long, and a total of 86,016 words.

This makes it 113% the length of the average book. It also has 105% more words than the average book.

How Long Does it Take to Read The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States Aloud?

The average oral reading speed is 183 words per minute. This means it takes 7 hours and 50 minutes to read The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States aloud.

What Reading Level is The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States?

The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

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Where Can I Buy The P53 Oligomerization Domain [microform] : Sequence-structure Relationships and the Design and Characterization of Altered Oligomeric States?

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