How Long to Read Tissue Fate Decisions in the Drosophila Eye-antennal Disc

How Long Does it Take to Read Tissue Fate Decisions in the Drosophila Eye-antennal Disc?

It takes the average reader to read Tissue Fate Decisions in the Drosophila Eye-antennal Disc by Alison J. Ordway

Assuming a reading speed of 250 words per minute. Learn more

Description

During development of an organism, there must be precise regulation of gene expression in order to ensure proper patterning of adult structures. This tight control ensures that adult structures are produced in the stereotypical place and number. This work aims to investigate how gene regulation drives organ number decisions using the fruit fly, Drosophila melanogaster, as a model. We study a developing tissue, the eye-antennal disc, which gives rise to the adult eye, antenna, and most of the head epidermis. We wanted to further investigate the roles of a tissue specific factor, Twin of eyeless (Toy), and a chromatin remodeler, the Nucleosome Remodeling Factor (NURF) complex, in controlling organ number in the eye-antennal disc. The reduction of NURF or Toy individually has minor developmental effects. However, when NURF and Toy are reduced simultaneously, the antennae duplicate - producing animals with four antennae instead the usual of two. Subsequently, we discovered the mechanism underlying this antennal duplication was a head capsule-to-antenna fate transformation. Next, we aimed to uncover downstream targets of the NURF complex in order to identify other factors involved in head capsule fate determination and, therefore, organ number control. This resulted in the identification of a likely target, Pointed (Pnt). Similar to NURF, the singular reduction of Pnt has little effect. However, reduction of Pnt and Toy in parallel produces antennal duplications. Results from this work highlight the combinatorial code of independently acting factors that contribute to development of a given tissue. Disruption of these factors individually has minor consequences, only reduction of both simultaneously sheds light on their cryptic developmental roles. While studying the fate transformation that gives rise to the antennal duplication phenotype, we discovered that blocking cell death in a NURF and Toy deficient animal drove a secondary duplication event, resulting in discs with up to four antennae. Further investigation of this phenotype suggests that a separate mechanism, axis duplication, may underlie this secondary duplication event. Together, this work examines the role of tissue fate and patterning in controlling organ number in the eye-antennal disc.

How long is Tissue Fate Decisions in the Drosophila Eye-antennal Disc?

Tissue Fate Decisions in the Drosophila Eye-antennal Disc by Alison J. Ordway is 0 pages long, and a total of 0 words.

This makes it 0% the length of the average book. It also has 0% more words than the average book.

How Long Does it Take to Read Tissue Fate Decisions in the Drosophila Eye-antennal Disc Aloud?

The average oral reading speed is 183 words per minute. This means it takes to read Tissue Fate Decisions in the Drosophila Eye-antennal Disc aloud.

What Reading Level is Tissue Fate Decisions in the Drosophila Eye-antennal Disc?

Tissue Fate Decisions in the Drosophila Eye-antennal Disc is suitable for students ages 2 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Tissue Fate Decisions in the Drosophila Eye-antennal Disc?

Tissue Fate Decisions in the Drosophila Eye-antennal Disc by Alison J. Ordway is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

To buy Tissue Fate Decisions in the Drosophila Eye-antennal Disc by Alison J. Ordway on Amazon click the button below.