It takes the average reader 18 hours and 42 minutes to read 23 European Symposium on Computer Aided Process Engineering by Edward Close
Assuming a reading speed of 250 words per minute. Learn more
We demonstrate an approach to construct an adaptive design space in the face of process variability, for an industrial hydrophobic interaction chromatography (HIC) with resin lot-to-lot variability. The step has a complex mixture of impurities in the feed stream and a multi component product. The step must deliver a specific distribution of product forms in the elution peak whilst maintaining product recovery and impurity removal. In our approach, a mechanistic model is used which gives a good representation of the system, and has been validated experimentally. The model is used to quickly and efficiently explore the impact of process parameters on process performance, utilizing stochastic simulation to generate probabilistic design spaces for different resin lots. The results indicate that significant increases in process robustness can be made by adapting the design space based on the resin lot in use, rather than fixing the design space for all resin lots. An adaptive design space enables operation further away from high risk regions, increases the size of operating regions and improves flexibility to variations in process inputs.
23 European Symposium on Computer Aided Process Engineering by Edward Close is 1,088 pages long, and a total of 280,704 words.
This makes it 367% the length of the average book. It also has 343% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 25 hours and 33 minutes to read 23 European Symposium on Computer Aided Process Engineering aloud.
23 European Symposium on Computer Aided Process Engineering is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
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