How Long to Read Alzheimer Disease

How Long Does it Take to Read Alzheimer Disease?

It takes the average reader 8 hours and 30 minutes to read Alzheimer Disease by Ezio Giacobini

Assuming a reading speed of 250 words per minute. Learn more

Description

Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.

How long is Alzheimer Disease?

Alzheimer Disease by Ezio Giacobini is 510 pages long, and a total of 127,500 words.

This makes it 172% the length of the average book. It also has 156% more words than the average book.

How Long Does it Take to Read Alzheimer Disease Aloud?

The average oral reading speed is 183 words per minute. This means it takes 11 hours and 36 minutes to read Alzheimer Disease aloud.

What Reading Level is Alzheimer Disease?

Alzheimer Disease is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Alzheimer Disease?

Alzheimer Disease by Ezio Giacobini is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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