It takes the average reader 6 hours and 9 minutes to read Antibody Fc by Marije B. Overdijk
Assuming a reading speed of 250 words per minute. Learn more
Historically, lack of specificity for cancer cells has been a major problem in cancer treatment; however, the development of monoclonal antibodies (mAbs), which combine high specificity with multiple mechanisms of action (MoAs), started a revolution in anti-cancer treatment options which continues to date. As of January 2013, 15 major antibody products were being marketed for cancer treatment in various countries around the globe, 10 of which are unmodified mAbs, which generally have multiple potential MoAs and may act via direct, Fab-domain-related effects or indirect, Fc-domain-related effects. Fc-domain-related effects consist of immune-mediated effector functions, which include complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP). ADCC and ADCP depend on the engagement of Fcγ-receptors (FcγR) on immune effector cells by Fc-domains clustered due to antibody–antigen binding. Similarly, CDC depends on the engagement of proteins of the complement system by clustered antibody Fc domains. In this chapter, preclinical and clinical studies with approved anti-cancer mAbs are reviewed, with an emphasis on the role of FcγR-mediated effector functions. The importance of therapeutic antibody–FcγR interactions for human treatment can be deduced from correlations of clinical responses with FcγR polymorphisms, results supported by a wealth of preclinical and in vitro studies.
Antibody Fc by Marije B. Overdijk is 358 pages long, and a total of 92,364 words.
This makes it 121% the length of the average book. It also has 113% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 8 hours and 24 minutes to read Antibody Fc aloud.
Antibody Fc is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
Antibody Fc by Marije B. Overdijk is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.
To buy Antibody Fc by Marije B. Overdijk on Amazon click the button below.
Buy Antibody Fc on Amazon