It takes the average reader 6 hours to read Autophagy by Tomohiro Kabuta
Assuming a reading speed of 250 words per minute. Learn more
To date, three forms of autophagy – macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA) – have been identified. Recently, we discovered a novel type of autophagy, “RNautophagy,” in which RNA is taken up directly into lysosomes for degradation. Gain of toxic functions of accumulated misfolded proteins or abnormal RNAs in CNS participate to a considerable degree in the pathogenesis of various neurodegenerative diseases. Thus, degradation and clearance of the toxic species by autophagy systems may be important for the maintenance of neurons and prevention of neurodegenerative diseases. We showed that amyotrophic lateral sclerosis (ALS)-linked mutant SOD1 is degraded not only by the proteasome but also by macroautophagy, and that macroautophagy reduces mutant SOD1-mediated toxicity. We found that Parkinson’s disease-associated mutant UCH-L1 interacts with LAMP-2A and Hsc70, which are the components of CMA machinery, and inhibits CMA. Because RNAs containing aberrant repeats are thought to cause some of ALS or spinocerebellar ataxia (SCA), RNautophagy may also play significant roles in the pathology of neurodegenerative diseases.
Autophagy by Tomohiro Kabuta is 360 pages long, and a total of 90,000 words.
This makes it 121% the length of the average book. It also has 110% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 8 hours and 11 minutes to read Autophagy aloud.
Autophagy is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
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