It takes the average reader 6 hours to read Autophagy by Rafael Guerrero-Preston
Assuming a reading speed of 250 words per minute. Learn more
Platinum chemotherapy is beneficial for human epithelial cancers because the platinum agents induce DNA damage signaling, leading to initiation of cell cycle arrest and apoptosis, and ultimately to tumor cell death. However, tumor cells often develop chemoresistance to platinum anticancer drugs, because of the initiation of autophagic pathways serving as a cell-protective mechanism against these chemical stresses. Although the molecular events underlying these events are not yet completely understood, the critical role of tumor protein (TP)-p53 family members, as key players in guarding the genome and proteome integrity under stress, is very much appreciated. As transcriptional factors, TP53 members exert their functions through the transcriptional regulation of genes encoding the autophagic intermediates, while also affecting the transcription of microRNA by inducing or reducing their expression in tumor cells sensitive or resistant to chemotherapeutic anticancer drugs. These microRNAs subsequently modulate the expression of autophagic proteins and are very likely to change the molecular landscape of tumor-cell response to the anticancer drugs. Thus, a clear and in-depth understanding of molecular pathways leading to modulation of autophagic intermediates through transcription, microRNA modulation, and protein–protein interactions would lead to potentially beneficial adjustments of existing chemotherapeutics supplemented with small molecule- or microRNA-based regimens.
Autophagy by Rafael Guerrero-Preston is 360 pages long, and a total of 90,000 words.
This makes it 121% the length of the average book. It also has 110% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 8 hours and 11 minutes to read Autophagy aloud.
Autophagy is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
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