How Long to Read Computational Drug Design Applied to Neglected Disease

How Long Does it Take to Read Computational Drug Design Applied to Neglected Disease?

It takes the average reader 4 hours and 7 minutes to read Computational Drug Design Applied to Neglected Disease by Jacob Devin Durrant

Assuming a reading speed of 250 words per minute. Learn more

Description

Herein is described the identification of novel inhibitors of key pathogenic proteins, the use of established computational techniques to further drug discovery, and the development of novel computational methods, with the ultimate goal of identifying small-molecule compounds that, with further development, may serve as future treatments for neglected diseases. Two of the pathogens targeted, Trypanosoma brucei and Trypanosoma cruzi, are neglected because they are tropical, and drugs marketed solely to the developing world are rarely profitable. A third disease, H1N1 pandemic influenza, is somewhat neglected because it is only now emergent. For Trypanosoma brucei, two drug-discovery projects are described, focusing on two crucial enzymes : UDP-galactose 4'-epimerase and RNA editing ligase 1. For Trypanosoma cruzi, the dynamics of cruzain, a crucial cysteine protease, are studied and characterized. Finally, for influenza, predicted inhibitors of neuraminidase (N1) are presented. Aside from describing identified enzyme inhibitors, the current work also describes several new methods that may be generally applicable to drug discovery. These new methods include a multidimensional strategy for the identification of secondary targets of known small-molecule inhibitors in the absence of global structural and sequence homology with the primary target protein, a novel computer-aided drug design algorithm (AutoGrow) that combines the strengths of both fragment-based growing and docking algorithms, and an extension to the relaxed complex scheme that accounts for both population-shift and induced-fit contributions to ligand binding.

How long is Computational Drug Design Applied to Neglected Disease?

Computational Drug Design Applied to Neglected Disease by Jacob Devin Durrant is 239 pages long, and a total of 61,901 words.

This makes it 81% the length of the average book. It also has 76% more words than the average book.

How Long Does it Take to Read Computational Drug Design Applied to Neglected Disease Aloud?

The average oral reading speed is 183 words per minute. This means it takes 5 hours and 38 minutes to read Computational Drug Design Applied to Neglected Disease aloud.

What Reading Level is Computational Drug Design Applied to Neglected Disease?

Computational Drug Design Applied to Neglected Disease is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Computational Drug Design Applied to Neglected Disease?

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