It takes the average reader 2 hours and 29 minutes to read DNA Methylation and Cellular Differentiation by James H. Taylor
Assuming a reading speed of 250 words per minute. Learn more
In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic developmental stages for maintenance and de novo type methylase activity. With one exception the referees, probably developmental biologists, recommended that the work not be supported because there was no evidence that methylation plays any role in eukaryotic gene regulation. Aside from proving that innovative ideas can seldom be used to successfully compete for grant funds, the skepticism of biologists toward methylation as a regulatory mechanism was, and still is, widespread even among some of those who investigate the problem. That is a healthy situation for all points of view should be brought to bear on a problem of such importance. However, to deny funds to investigate a problem because one has already formed an opinion without evidence is hardly commendable. The great skepticism about the significance of DNA methylation is based in part on the evidence that it is absent or very little used in Drosophila, a favorite organism for genetic and developmental studies. There now remains little doubt that methylation of cytosine in certain CpG sites can strikingly affect the transcription of sequences 3' to the methylated doublet. How this inhibition operates and to what extent it is utilized in cells is still debatable.
DNA Methylation and Cellular Differentiation by James H. Taylor is 146 pages long, and a total of 37,376 words.
This makes it 49% the length of the average book. It also has 46% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 3 hours and 24 minutes to read DNA Methylation and Cellular Differentiation aloud.
DNA Methylation and Cellular Differentiation is suitable for students ages 10 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
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