It takes the average reader 4 hours and 20 minutes to read Ensnaring the Pancreatic [alpha]-cell & Syntaxin 1A Modulation of the [alpha]-cell K[subscript]v4.3 Channel by Ishtiaq Ahmed
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Immunohistochemical and electrophysiological characterization of alpha- and beta-cells confirmed the viability of the GFP-labelling technique for examining islet cells. Furthermore, we demonstrated a large variance in beta-cell sizes with potential functional consequences. Pancreatic islet alpha- and beta-cells secrete glucagon and insulin respectively to maintain glucose homeostasis. Study of alpha-cells is limited by difficulties in isolating and identifying them and therefore little is known concerning regulation of alpha-cell membrane excitability and exocytosis. This thesis (1) assesses a new technique for efficient detection of alpha-cells in a transgenic mouse model expressing GFP-labelled beta-cells and (2) subsequently studies the alpha-cell Kv4.3 channel and its potential regulation by syntaxin 1A (Syn1A), a SNARE protein involved in modulating cell excitability and exocytosis. Our results also indicate that Kv4.3, which significantly shapes action potentials, is less responsive to Syn1A induced inhibition than other Kv channels and that Syn1A - Kv interactions are diverse and dynamic in nature.
Ensnaring the Pancreatic [alpha]-cell & Syntaxin 1A Modulation of the [alpha]-cell K[subscript]v4.3 Channel by Ishtiaq Ahmed is 260 pages long, and a total of 65,000 words.
This makes it 88% the length of the average book. It also has 79% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 5 hours and 55 minutes to read Ensnaring the Pancreatic [alpha]-cell & Syntaxin 1A Modulation of the [alpha]-cell K[subscript]v4.3 Channel aloud.
Ensnaring the Pancreatic [alpha]-cell & Syntaxin 1A Modulation of the [alpha]-cell K[subscript]v4.3 Channel is suitable for students ages 12 and up.
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