It takes the average reader 3 hours and 44 minutes to read Interactions of Surfactant Protein D with the Glycoproteins Ovalbumin and Alpha-2-macroglobulin by Hayley Craig-Barnes
Assuming a reading speed of 250 words per minute. Learn more
Surfactant protein D (SP-D) is an important innate immune collectin involved in uptake and clearance of microbes and allergens in the lungs. SP-D has been shown to ameliorate allergic asthma reactions in mice; however, the mechanisms for this are not fully understood. We investigated the role of SP-D in the uptake and clearance of the model allergen ovalbumin (OVA) by macrophages. We discovered that SP-D does not bind OVA but binds fractions with contaminating proteins; ovomucin and ovomacroglobulin. We extended these findings to show that SP-D binds human alpha-2-macroglobulin (A2M) in its cleaved or intact state, in a concentration-, calcium-, and carbohydrate-dependent manner. A2M increases the innate immune potential of SP-D by increasing its ability to agglutinate the bacteria Escherichia coli and Bacillus subtilis. We found that SP-D does not increase the uptake of OVA by murine macrophage cell lines, or by alveolar macrophages in vivo in BALB/cJ mice.
Interactions of Surfactant Protein D with the Glycoproteins Ovalbumin and Alpha-2-macroglobulin by Hayley Craig-Barnes is 218 pages long, and a total of 56,244 words.
This makes it 74% the length of the average book. It also has 69% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 5 hours and 7 minutes to read Interactions of Surfactant Protein D with the Glycoproteins Ovalbumin and Alpha-2-macroglobulin aloud.
Interactions of Surfactant Protein D with the Glycoproteins Ovalbumin and Alpha-2-macroglobulin is suitable for students ages 12 and up.
Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.
When deciding what to show young students always use your best judgement and consult a professional.
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