It takes the average reader and 57 minutes to read Mass Spectrometry Guided Analogs of Bioactive Molecule Discovery by Yao Peng
Assuming a reading speed of 250 words per minute. Learn more
Recently, there has been remarkable interest in mining the chemical diversity in specialized metabolites scaffolds to identify novel molecules with altered bioactivity from natural source. Here, we present the use of MS/MS networking guided comparative metabolomics to profile sequenced and unsequenced bacteria. This enables the dereplication of known specialized metabolites as well as the discovery of new analogs that are produced in an environmental unsequenced bacterium Streptomyces sp. DSM5940 by comparing the metabolic output with a sequenced bacterium Streptomyces roseosporus. The following differential comparison of gene cluster profiling, MS/MS and 2D NMR greatly accelerates the structure elucidation process, allowing us to rapidly identify an analog of the stenothricins in which a lysine is changed to a serine, which we have named stenothrisercin. The finally cytological profiling indicates lysine may be an essential structural motif for the antimicrobial activity. Our study demonstrates MS/MS networking, along with differential comparison significantly accelerates the process of mining new natural product analogs.
Mass Spectrometry Guided Analogs of Bioactive Molecule Discovery by Yao Peng is 56 pages long, and a total of 14,336 words.
This makes it 19% the length of the average book. It also has 18% more words than the average book.
The average oral reading speed is 183 words per minute. This means it takes 1 hour and 18 minutes to read Mass Spectrometry Guided Analogs of Bioactive Molecule Discovery aloud.
Mass Spectrometry Guided Analogs of Bioactive Molecule Discovery is suitable for students ages 8 and up.
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