How Long to Read Molecular Genetics of Thalassemia Syndromes

How Long Does it Take to Read Molecular Genetics of Thalassemia Syndromes?

It takes the average reader and 59 minutes to read Molecular Genetics of Thalassemia Syndromes by Reena Das

Assuming a reading speed of 250 words per minute. Learn more

Description

This book reviews the molecular genetics of the thalassemia syndromes, inherited hemoglobin disorders that comprise the commonest monogenic disorders globally. Thalassemias are found in high frequencies in tropical regions corresponding to the malaria belt. Beta thalassemia traits show high HbA2 by HPLC, and β-globin mutations (commonly point mutations) are detected by using ARMS-PCR, reverse dot-blot analysis and β-globin gene sequencing. Globally >300 β globin gene mutations exist, however regional mutations are limited to 5-6 common ones. Alpha globin gene defects can only be identified by molecular tests, the exception being HbH disease that shows "golf ball" appearance in HbH preparation, pre-integration peaks on HPLC and a fast-moving band on hemoglobin electrophoresis. Multiplex Gap-PCR identifies common α-globin gene deletions. Specific PCR across the junction caused by the unequal crossing over can detect α-gene triplication. However, heterozygosity or homozygous triplication cannot be resolved by this technique. Non-deletional α-thalassemia can be characterized by specific α-globin gene sequencing. Identification of unusual deletions requires Multiplex Ligation-dependent Probe Amplification. In conclusion, the molecular characterization of human globin gene disorders is required to resolve the phenotypically heterogeneous thalassemia syndromes. Molecular analysis is also an important tool to prevent these disorders by offering prenatal screening in regions with a high disease burden.

How long is Molecular Genetics of Thalassemia Syndromes?

Molecular Genetics of Thalassemia Syndromes by Reena Das is 58 pages long, and a total of 14,964 words.

This makes it 20% the length of the average book. It also has 18% more words than the average book.

How Long Does it Take to Read Molecular Genetics of Thalassemia Syndromes Aloud?

The average oral reading speed is 183 words per minute. This means it takes 1 hour and 21 minutes to read Molecular Genetics of Thalassemia Syndromes aloud.

What Reading Level is Molecular Genetics of Thalassemia Syndromes?

Molecular Genetics of Thalassemia Syndromes is suitable for students ages 8 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Molecular Genetics of Thalassemia Syndromes?

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