How Long to Read Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion

How Long Does it Take to Read Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion?

It takes the average reader 4 hours and 18 minutes to read Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion by Amandeep Singh Thind

Assuming a reading speed of 250 words per minute. Learn more

Description

Revascularization of Chronic Total Occlusions (CTO) by percutaneous coronary interventions is limited by low success rates, primarily due to difficulty in guidewire crossing. There are a number of contributing factors that make guidewire crossing challenging. Two of the most significant impediments are: a) inability to adequately visualize the CTO to appropriately plan a pathway to the distal lumen, and b) difficulty in physically crossing the rigid endcap at the proximal end of CTO without using stiff wires. Moreover, there is a significant knowledge gap in the composition of CTOs, and the consequent impact of that composition on crossability.Recent studies have suggested that the presence of microvessels in CTO may provide a preferred pathway for guidewire crossing. However, due to limited resolution and a lack of soft tissue contrast in angiography, microvessels within CTO cannot generally be detected by in-vivo angiographic techniques, and when they are visualized, it is unknown whether or not they are intraluminal. In this thesis, high frequency ultrasound with Power Doppler overlays is shown to be capable of detecting and tracking transluminal recanalization channels using an in vivo porcine model of CTO. It is also shown that ultrasound is a more sensitive technique to detect and map these channels than MRI. Furthermore, features of microvasculature in CTOs that had not previously been seen are presented.A technique was then developed to facilitate guidewire crossing through the proximal endcap, also known as the proximal fibrous cap (PFC). In order to assess the ease with which a probe is able to perforate the PFC, a system was designed and to measure the force required for PFC puncture. This system was validated by examining the required puncture forces for CTOs of different ages. It was shown that CTOs less than 6 weeks in age are significantly easier to puncture than those greater than 12 weeks. This coincides with differences in composition, with the presence of softer materials at the earlier time point, such as thrombus and proteoglycans compared to stiffer fibrotic materials which predominate at late timepoints.This thesis presents tools and techniques to help mitigate the current shortcomings, while shedding new light on CTO composition and maturation. The tools and techniques presented herein are based upon ultrasound approaches with the intent of eventually developing these strategies into catheter based solutions.After development and validation of a reliable technique to measure ease of PFC puncture, the efficacy of therapies designed to modify PFC compliance could be assessed. The use of ultrasound mediated microbubble (UMM) disruption to act as an adjuvant to accelerate collagenase therapy in CTO was examined. A significant reduction in puncture force and an increase in the amount of collagen degraded was achieved using a combined UMM + collagenase treatment compared with collagenase therapy alone and UMM treatment alone.

How long is Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion?

Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion by Amandeep Singh Thind is 254 pages long, and a total of 64,516 words.

This makes it 86% the length of the average book. It also has 79% more words than the average book.

How Long Does it Take to Read Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion Aloud?

The average oral reading speed is 183 words per minute. This means it takes 5 hours and 52 minutes to read Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion aloud.

What Reading Level is Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion?

Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion?

Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion by Amandeep Singh Thind is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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