How Long to Read Protein Association in the Membrane, Mitochondria, and Cytosol

How Long Does it Take to Read Protein Association in the Membrane, Mitochondria, and Cytosol?

It takes the average reader 2 hours and 44 minutes to read Protein Association in the Membrane, Mitochondria, and Cytosol by James B. Fields

Assuming a reading speed of 250 words per minute. Learn more

Description

Protein-protein interactions (PPIs) play a crucial role in the regulation of protein activity, and are therefor of great importance in biology. Interactions between proteins require a certain degree of specificity, as the functional regulation of a protein needs to occur within a particular signal cascade and cannot be triggered by non-native interactions. At the same time, most PPIs are dominated by long- range coulombic interactions, which attract positively and negatively charged proteins, or patches of a protein, towards each other. In cases where the secondary structures of the two interacting proteins in infinite dilution are complementary towards the formation of the active complex, the association rate constant becomes diffusion-limited. However, many active protein complexes require some degree of conformational sampling after the formation of the initial encounter, which adds a second rate-limiting step.xv.The work presented herein details the molecular association and regulatory mechanisms of three unique protein complexes. The primary methods that I employed in this dissertation include two forms of atomistic dynamics simulations, specifically molecular dynamics (MD) and Brownian dynamics (BD), which I use both separately and in tandem. First, I discuss my BD/MD generated model of the cytochrome P450cin/Cindoxin complex. Very few crystal structures exist of cytochrome P450 protein complexes. Our BD/MD complex allowed us to characterize the electron transfer pathway in the P450cin/Cindoxin complex. In another case where a complex crystal structure was previously solved, the Leishmania major peroxidase-cytochrome c complex, BD simulations helped to reveal the first encounter site that plays a role in the formation of the active complex. Finally, I detail the regulation of the water channel protein, aquaporin 0 (AQP0) by external calcium concentration, phosphorylation, and pH.

How long is Protein Association in the Membrane, Mitochondria, and Cytosol?

Protein Association in the Membrane, Mitochondria, and Cytosol by James B. Fields is 159 pages long, and a total of 41,181 words.

This makes it 54% the length of the average book. It also has 50% more words than the average book.

How Long Does it Take to Read Protein Association in the Membrane, Mitochondria, and Cytosol Aloud?

The average oral reading speed is 183 words per minute. This means it takes 3 hours and 45 minutes to read Protein Association in the Membrane, Mitochondria, and Cytosol aloud.

What Reading Level is Protein Association in the Membrane, Mitochondria, and Cytosol?

Protein Association in the Membrane, Mitochondria, and Cytosol is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

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