How Long to Read The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy

How Long Does it Take to Read The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy?

It takes the average reader 2 hours and 1 minute to read The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy by Tanya Jean Wyatt

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Description

Infantile spinal muscular atrophy (SMA) is the most common and severe hereditary neurological disease in childhood. Children diagnosed with SMA demonstrate severe muscle weakness that makes it difficult for them to breathe, eat, and move. SMA is characterized by the loss of motor neurons within the spinal cord that are pertinent to maintaining functional connections with muscle, and thus allowing for muscle contraction and movement. The loss of motor neurons in the most severe form of the disease, known as Type I SMA, results in muscle atrophy and paralysis, which eventually becomes fatal within the first 2 years due to respiratory failure. Currently, there is no treatment that can change the course of the disease. This study set out to determine the effect(s) of transplanting human embryonic stem cell (hESC)-derived motor neuron progenitors (hMNPs) into the spinal cord of three established murine models of motor neuron loss, each depicting similar motor neuron pathology as seen in human SMA. The repair potential of the transplanted cells was analyzed and any functional benefit that was conferred upon the animals following transplantation was recorded. Our results demonstrate stable maturation of the transplant cell population, sparing of host neurons and muscle, maturation of NMJs, functional benefit, improved vital signs, and an increase in longevity following transplantation. The beneficial outcomes noted in the hMNP-treated animals are likely a result of increasing growth factor concentration within the spinal cord and neighboring tissues. hMNPs represent a biological tool to investigate human motor neuron development and disease. They can be used to provide clinicians and researchers alike with a clinically relevant cell population for the development of translatable therapies aimed at treating those affected by SMA or other similar diseases of motor neuron loss.

How long is The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy?

The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy by Tanya Jean Wyatt is 118 pages long, and a total of 30,444 words.

This makes it 40% the length of the average book. It also has 37% more words than the average book.

How Long Does it Take to Read The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy Aloud?

The average oral reading speed is 183 words per minute. This means it takes 2 hours and 46 minutes to read The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy aloud.

What Reading Level is The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy?

The Physiological Relevance of HMNP Transplantation Into the SMNdelta7 Murine Model of Spinal Muscular Atrophy is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

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