How Long to Read The Role of Neck and Hinge for the Mechanism of Conventional Kinesins

By Friederike Bathe

How Long Does it Take to Read The Role of Neck and Hinge for the Mechanism of Conventional Kinesins?

It takes the average reader 2 hours and 19 minutes to read The Role of Neck and Hinge for the Mechanism of Conventional Kinesins by Friederike Bathe

Assuming a reading speed of 250 words per minute. Learn more

Description

Conventional kinesins are molecular motors that walk along microtubules to carry out a large variety of cellular transport processes. The conventional kinesin of the filamentous fungus Neurospora crassa is 3-4 times faster than its animal relatives. Its neck domain displays characteristic properties that is also reflected in a specific sequence pattern. In the present work the functional roles of the specific neck and hinge domains for mechano-chemistry, dimerization and regulation of fast fungal kinesins are investigated. To address this issue, mutant protein constructs were generated, and characterized in terms of oligomerization, motility and kinetic properties. The results show that the specific neck and hinge regions are not critical for the basic mechanism of fast fungal kinesins. However, they play an important role for the regulation of the motor in a dimerization-based mechanism. In addition, the specific neck sequences may have evolved to fine-tune kinesin's processivity by combining tight structural connection of the head domains with a flexible tether that facilitates the diffusive search for the next microtubule binding site.

How long is The Role of Neck and Hinge for the Mechanism of Conventional Kinesins?

The Role of Neck and Hinge for the Mechanism of Conventional Kinesins by Friederike Bathe is 136 pages long, and a total of 34,816 words.

This makes it 46% the length of the average book. It also has 43% more words than the average book.

How Long Does it Take to Read The Role of Neck and Hinge for the Mechanism of Conventional Kinesins Aloud?

The average oral reading speed is 183 words per minute. This means it takes 3 hours and 10 minutes to read The Role of Neck and Hinge for the Mechanism of Conventional Kinesins aloud.

What Reading Level is The Role of Neck and Hinge for the Mechanism of Conventional Kinesins?

The Role of Neck and Hinge for the Mechanism of Conventional Kinesins is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

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