How Long to Read Therapeutic Potential of Furin Inhibition

How Long Does it Take to Read Therapeutic Potential of Furin Inhibition?

It takes the average reader and 32 minutes to read Therapeutic Potential of Furin Inhibition by Jeroen Declercq

Assuming a reading speed of 250 words per minute. Learn more

Description

The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity. Therefore, it is not surprising that it plays a major role in many physiological processes and pathologies, including cancer. The other proprotein convertases belonging to the same family, PC1/3, PC2, PACE4, PC4, PC5/6, and PC7, cleave at similar cleavage sites and provide partial redundancy. To unravel the specific role of Furin in vivo, knockout mouse models have been generated. Furin null mice die between e10.5 and e11.5 due to severe ventral closure defects and the failure of the heart tube to fuse and undergo looping morphogenesis. Therefore, a conditional Furin knockout mouse was generated to investigate the role of Furin in specific organs, such as pancreas, liver, T-cells, endothelial cells, and salivary glands, resulting in a severe or mild phenotype depending on the organ investigated. Partial or complete ablation of the Fur gene in salivary gland tumors significantly delayed tumorigenesis in mice. Therefore, Furin inhibition might be considered as a possible therapeutic strategy to treat certain pathologies, such as cancer.

How long is Therapeutic Potential of Furin Inhibition?

Therapeutic Potential of Furin Inhibition by Jeroen Declercq is 32 pages long, and a total of 8,064 words.

This makes it 11% the length of the average book. It also has 10% more words than the average book.

How Long Does it Take to Read Therapeutic Potential of Furin Inhibition Aloud?

The average oral reading speed is 183 words per minute. This means it takes and 44 minutes to read Therapeutic Potential of Furin Inhibition aloud.

What Reading Level is Therapeutic Potential of Furin Inhibition?

Therapeutic Potential of Furin Inhibition is suitable for students ages 8 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Therapeutic Potential of Furin Inhibition?

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