How Long to Read Ubiquitin Chains: Degradation and Beyond

How Long Does it Take to Read Ubiquitin Chains: Degradation and Beyond?

It takes the average reader 1 hour and 44 minutes to read Ubiquitin Chains: Degradation and Beyond by Arnab De

Assuming a reading speed of 250 words per minute. Learn more

Description

This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a knock-in mouse that expresses a mutated form of A20 which selectively lacks the deubiquitinase activity. The knock-in mice surprisingly display completely normal NF-κB activation with no accompanying inflammatory phenotype. Given that the presumed role of A20 as a deubiquitinase has been used to support the importance of regulatory K63-linked ubiquitination in NF-kB signaling, this study will help focus future research efforts into alternative target pathways that do not depend on K63 ubiquitination. In fact, the work suggests that it might be important to revisit the role of K63-linked polyubiquitination in cell-signalling. Ubiquitin Chains: Degradation and Beyond is essential reading for anyone conducting research in cell-signalling and immunology. Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted in multiple patents and publications in peer reviewed journals. He presented his findings at the American Peptide Symposium and was awarded the Young Investigator’s Award. He is the author of the book entitled Application of Peptide-Based Prodrug Chemistry in Drug Development, with a foreword written by Professor Jean Martinez (Former President, European Peptide Society) and published in the series SpringerBriefs in Pharmaceutical Science & Drug Development. His research interests lie at the intersection of chemistry and medicine. Besides biomedical research, he is also generally interested in public health policy and general scientific outreach.

How long is Ubiquitin Chains: Degradation and Beyond?

Ubiquitin Chains: Degradation and Beyond by Arnab De is 103 pages long, and a total of 26,059 words.

This makes it 35% the length of the average book. It also has 32% more words than the average book.

How Long Does it Take to Read Ubiquitin Chains: Degradation and Beyond Aloud?

The average oral reading speed is 183 words per minute. This means it takes 2 hours and 22 minutes to read Ubiquitin Chains: Degradation and Beyond aloud.

What Reading Level is Ubiquitin Chains: Degradation and Beyond?

Ubiquitin Chains: Degradation and Beyond is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Ubiquitin Chains: Degradation and Beyond?

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