How Long to Read Nuclear and Cytoplasmic Roles of the Transcription Factor REST

How Long Does it Take to Read Nuclear and Cytoplasmic Roles of the Transcription Factor REST?

It takes the average reader 1 hour and 1 minute to read Nuclear and Cytoplasmic Roles of the Transcription Factor REST by Anthony Vu

Assuming a reading speed of 250 words per minute. Learn more

Description

The neuron-restrictive silencer factor (NRSF), also known as repressor element -1 (RE1) silencing transcription factor (REST), is known to act as a transcriptional repressor of neuron-specific genes in nuclei of non-neuronal cells. REST binds a DNA sequence known as neuron-restrictive silencer elements (NRSEs/RE1s) and recruits co-repressors to carry out silencing chromatin modifications. Recent REST ChIP-seq publications have shown that REST binding is not limited to the canonical RE1 sequence, but binds multiple variations of it across the genome. This study focuses on determining REST's capacity to act as a repressor based on the binding site's degree of correspondence to the canonical RE1 motif. I show that the RE1 right half site acts as a REST-recruiting repressive element. I have also begun studying differential recruitment of REST protein and its cofactors between human embryonic stem cells (hESCs) and hESC-derived neural progenitor cells (NPCs) on a genome-wide scale using chromatin immunoprecipitation followed by massive parallel sequencing of DNA tags (ChIP-seq). I also present preliminary data suggesting that REST may have a second function as a post-transcriptional activator. Increased luciferase expression is observed when reporter constructs were cotransfected with high levels of REST in mouse Neuro2A (N2A) cells. I show that this concentration dependent function of REST is due to the cell's limited capacity to transport and/or retain REST in the nucleus, where it acts as a repressor. With increasing concentrations of REST, a large fraction remains in the cytoplasm, where REST may bind and stabilize the luciferase transcript and/or enhance its translation.

How long is Nuclear and Cytoplasmic Roles of the Transcription Factor REST?

Nuclear and Cytoplasmic Roles of the Transcription Factor REST by Anthony Vu is 61 pages long, and a total of 15,311 words.

This makes it 21% the length of the average book. It also has 19% more words than the average book.

How Long Does it Take to Read Nuclear and Cytoplasmic Roles of the Transcription Factor REST Aloud?

The average oral reading speed is 183 words per minute. This means it takes 1 hour and 23 minutes to read Nuclear and Cytoplasmic Roles of the Transcription Factor REST aloud.

What Reading Level is Nuclear and Cytoplasmic Roles of the Transcription Factor REST?

Nuclear and Cytoplasmic Roles of the Transcription Factor REST is suitable for students ages 8 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Nuclear and Cytoplasmic Roles of the Transcription Factor REST?

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