How Long to Read The Role of Notch Signaling During T Cell Commitment and Differentiation [microform]

How Long Does it Take to Read The Role of Notch Signaling During T Cell Commitment and Differentiation [microform]?

It takes the average reader 4 hours and 44 minutes to read The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] by Thomas M. (Thomas Michael) Schmitt

Assuming a reading speed of 250 words per minute. Learn more

Description

The nature of the molecular interactions provided by the thymus that predicate T cell development remains obscure. In this thesis, I demonstrate that the bone marrow (BM) stromal cell line OP9, when made to express the Notch ligand Delta-like-1 (Dll1), loses its ability to support B cell lymphopoiesis, and acquires the capacity to induce the development of CD4 CD8 double- and single-positive T cells from various hematopoietic progenitor cells. Both gammadelta-TCR + and alphabeta-TCR+ T cells are generated, and CD4- CD8+ TCRhi cells produce gamma-interferon following CD3/TCR stimulation. Dll1 expressed on OP9 cells provides the necessary signals to induce T cell commitment, stage-specific progenitor expansion, TCR gene rearrangement, and T cell differentiation in-vitro. A normal program of T cell differentiation was also observed from embryonic stem cells (ESCs) cultured on these OP9 cells, which expressed multiple T lineage-associated genes in response to Notch receptor-Dll1 interactions. Furthermore, ESC-derived T cell progenitors effectively reconstituted the T cell compartment of immunodeficient mice, and were capable of generating an antigen specific response to a viral challenge. Using this culture system, I demonstrate that a substantial proportion of early thymocytes retain NK cell lineage potential, and that Notch signals act prior to T cell lineage commitment to maintain T cell lineage specification in early thymocytes. Furthermore, Notch receptor-ligand interactions are shown to be critical throughout T cell development. Thus, it is likely that the expression of Delta-like ligands in the thymus underpins its unique ability to promote T cell lineage commitment and differentiation.

How long is The Role of Notch Signaling During T Cell Commitment and Differentiation [microform]?

The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] by Thomas M. (Thomas Michael) Schmitt is 282 pages long, and a total of 71,064 words.

This makes it 95% the length of the average book. It also has 87% more words than the average book.

How Long Does it Take to Read The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] Aloud?

The average oral reading speed is 183 words per minute. This means it takes 6 hours and 28 minutes to read The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] aloud.

What Reading Level is The Role of Notch Signaling During T Cell Commitment and Differentiation [microform]?

The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] is suitable for students ages 12 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy The Role of Notch Signaling During T Cell Commitment and Differentiation [microform]?

The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] by Thomas M. (Thomas Michael) Schmitt is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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